Can Low IgG Levels Cause Fatigue?

What does IgG blood test show?

What is an immunoglobulins blood test.

This test measures the amount of immunoglobulins, also known as antibodies, in your blood.

Antibodies are proteins made by the immune system to fight disease-causing substances, like viruses and bacteria..

What are the symptoms of low IgG?

What are the symptoms of an IgG deficiency?Sinus infections and other respiratory infections.Gastrointestinal infections.Ear infections.Pneumonia.Bronchitis.Infections that result in a sore throat.Rarely, severe and life-threatening infections.

What is considered a low IgG level?

Laboratory findings include profound hypogammaglobulinemia and extremely low to absent circulating B cells. Serum IgG levels are usually less than 200 mg/dL, and IgM and IgA levels are less than 20 mg/dL. Peripheral blood CD19+ B-cell counts are commonly less than 0.1%.

What are the most common autoimmune diseases?

According to The Autoimmune Registry, the top 10 most common autoimmune diseases include:Rheumatoid arthritis.Hashimoto’s autoimmune thyroiditis.Celiac disease.Graves’ disease.Diabetes mellitus, type 1.Vitiligo.Rheumatic fever.Pernicious anemia/atrophic gastritis.More items…•

How is low IgG treated?

Currently, the accepted therapy for IgG deficiency is the intravenous administration of 300-600 mg/kg of IgG once every 3-4 weeks, or 100-200 mg/kg/wk subcutaneously. Higher doses have been shown to be more effective in reducing infections in patients with histories of chronic or recurrent sinopulmonary infections.

Does CVID cause fatigue?

Patients with common variable immunodeficiency (CVID) have increased fatigue compared with the general population. Fatigue is associated with lower quality of life (QoL), which is associated with higher mortality in CVID.

What is the life expectancy of someone with CVID?

The life expectancy of CVID patients has considerably improved over the past 30 years [5, 63], from initially 12 years to currently over 50 years [3]. Reduced survival was significantly associated with age at diagnosis, lower baseline IgG, higher IgM and fewer peripheral B cells.

What is normal IgG level in adults?

Normal Ranges Adult: IgG 6.0 – 16.0g/L. IgA 0.8 – 3.0g/L. IgM 0.4 – 2.5g/L.

Is there a difference between autoimmune and immunodeficiency?

When your immune system fails to respond adequately to infection, it’s called an immunodeficiency. People may also suffer from the opposite condition, an overactive immune system that attacks healthy cells as though they were foreign bodies, and that is called an autoimmune response.

Does immunodeficiency cause fatigue?

Patients with primary immunodeficiency (PID) often report fatigue, yet this symptom has not been studied in PID. Fatigue affects 6–7.5% of healthy adults. The goal of this study is to estimate the prevalence of fatigue in patients with PID and investigate its associated factors.

Is IgG deficiency an autoimmune disease?

Autoimmune diseases were more frequent in CVID patients (37.1 %) than in those with selective IgA deficiency (25.5 %) or selective IgG subclass deficiency (12.5 %). Thirty-seven percent of autoimmune episodes occurred prior to the diagnosis of primary antibody deficiency.

What can cause low IgG levels?

Secondary IgG deficiency may be caused by:Aging.Malnutrition.Chemotherapy medicines and long-term corticosteroids.Infections such as HIV.